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Repetitive DNA sequences (TTAGGG) at chromosome ends that protect genetic information during cell division, progressively shortening with age.
Telomeres are repetitive nucleotide sequences (TTAGGG in vertebrates) and associated protein complexes at chromosome ends that protect genetic information from degradation and end-to-end fusion during cell division. With each replication, telomeres shorten by approximately 50-200 base pairs. When telomeres reach a critically short length (Hayflick limit), cells enter replicative senescence. Telomere length is considered a biomarker of cellular aging. The enzyme telomerase can partially counteract shortening, and its activity is influenced by oxidative stress, inflammation, and NAD+-dependent sirtuin activity. NAD+ supplementation research explores whether maintaining sirtuin function can support telomere maintenance.
BIOLOGY
General research term
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The irreversible state of cell cycle arrest in which cells remain metabolically active but stop dividing, contributing to tissue aging and chronic inflammation.
Nicotinamide Adenine Dinucleotide, an essential coenzyme in every living cell that drives energy metabolism, DNA repair, and sirtuin-mediated longevity pathways.
A collection of cellular processes that detect and correct damage to DNA molecules, essential for maintaining genomic integrity and preventing disease.
An imbalance between reactive oxygen species production and antioxidant defences, leading to cellular and molecular damage associated with aging and disease.
The active growth phase of the hair follicle cycle, lasting 2-7 years, during which the hair shaft elongates from a fully formed hair bulb.
A cluster of specialised mesenchymal cells at the base of the hair follicle that controls hair growth, cycling, and follicle regeneration.
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