How CJC-1295 Stimulates Growth Hormone
CJC-1295 is a synthetic analogue of Growth Hormone Releasing Hormone (GHRH). It binds to GHRH receptors on the pituitary gland, stimulating the production and release of growth hormone.
Key Features: - Extended half-life compared to natural GHRH - Produces sustained GH elevation (not just a single pulse) - Increases IGF-1 levels over time - Works at the hypothalamic-pituitary level
The sustained GH elevation produced by CJC-1295 is beneficial for research into body composition, recovery, and metabolic function.
How Ipamorelin Triggers GH Release
Ipamorelin is a selective growth hormone secretagogue that works through the ghrelin receptor (GHSR). Unlike other ghrelin mimetics, Ipamorelin is remarkably selective — it triggers GH release without significantly affecting cortisol, prolactin, or ACTH.
Key Features: - Highly selective GH release - Mimics natural pulsatile GH pattern - Minimal effect on appetite - Well-tolerated with few reported side effects - Does not desensitise receptors as quickly as other GHS compounds
The CJC-1295 + Ipamorelin Stack
The combination of CJC-1295 and Ipamorelin is one of the most widely studied GH peptide stacks:
CJC-1295 amplifies and extends the GH signal via the GHRH pathway Ipamorelin triggers additional GH pulses via the ghrelin pathway
Together, they produce a greater total GH release than either peptide alone.
Research Protocol Considerations: - Both administered simultaneously, preferably before bed - Duration: 8-12 week protocols are common - ORYN offers both at €109 each — €218 for the complete GH stack
