Mass Spectrometry

Mass spectrometry (MS) is a powerful analytical technique that ionises chemical compounds and sorts the resulting ions based on their mass-to-charge ratio (m/z), producing a mass spectrum that serves as a molecular fingerprint. In peptide analysis, techniques such as MALDI-TOF and ESI-MS are used to confirm peptide identity, determine molecular weight, verify amino acid sequence integrity, and detect impurities. When coupled with liquid chromatography (LC-MS), mass spectrometry provides both separation and identification capabilities, making it the gold standard for comprehensive peptide characterisation. ORYN utilises mass spectrometry as part of its quality control pipeline to verify that each batch meets the >99% purity specification and contains no unexpected contaminants or degradation products.