NAD+

Nicotinamide Adenine Dinucleotide (NAD+) is a critical coenzyme found in all living cells, functioning as an electron carrier in metabolic redox reactions including glycolysis, the citric acid cycle, and oxidative phosphorylation. Beyond its central role in energy metabolism, NAD+ serves as a substrate for several families of enzymes with profound implications for aging and repair: sirtuins (SIRT1-7), which regulate gene expression, DNA repair, and mitochondrial function; PARPs (poly-ADP-ribose polymerases), which are essential for DNA damage repair; and CD38/CD157 ectoenzymes involved in immune cell signalling. NAD+ levels decline significantly with age, contributing to mitochondrial dysfunction, impaired DNA repair, and the hallmarks of cellular senescence. This age-related decline has driven intense research interest in NAD+ precursors and direct NAD+ supplementation. ORYN offers both NAD+ Peptide Pen (500 mg) and NovaDose NAD+ cartridge system for precision daily microdosing with near-100% bioavailability.